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Proton pump inhibitors (acid blockers) and over-the-counter non-steroidal anti-inflammatory agents can change the environment of the GI tract predisposing to nutrient deficiencies Unfortunately, that isnt an exhaustive list, but it does give you a pretty good idea of why you should be concerned about your vitamin B12 levels

Xenical can also cause weakness, headache, back pain, cold symptoms, jaundice (yellowing of the eyes or skin), skin rash, itching, and teeth or gum problems 2

Many associate sufficient B12 levels with improved focus, mental clarity, and cognitive support