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Hyperpolarized [1-13C]pyruvate MRI can assess the balance between aerobic glycolysis (pyruvate-to-lactate conversion) and OXPHOS (pyruvate-to-TCA cycle flux), providing functional information about metabolic phenotypes

Supplementary Material Acknowledgments We thank Dr Erkki Ruoslahti of the Sanford-Burnham Medical Research Institute for providing us with a peptide display phage library and valuable suggestions

When semaglutide or tirzepatide degrades, the active compound breaks down into inactive fragments

For example, methods involving intravenous administration of glutathione are generally not practical for increasing circulating glutathione for most individuals because this procedure is expensive, requires regular visits to a medical practitioner's office, is unsuitable for children and many adults, and poses the risks of side effects associated with regular injections