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For example, consuming processed meats containing nitrates and nitrites, which are converted into nitric oxide (NO) in the body, can cause vasodilation, potentially altering cerebral blood flow and triggering migraines (Gonzalez et al., 2016)

PA and propionyl-CoA exert profound neurotoxicity by disrupting cellular energy metabolism and mitochondrial function, primarily through broad-spectrum inhibition of key metabolic enzymes, including pyruvate dehydrogenase (PDH) complex, KGDHC, succinyl-CoA ligase, N-acetylglutamate synthase (NAGS), Na + ,K + -ATPase, and MRC complex III (Klker et al

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10.1016/j.msard.2019.01.011 129 SailerM.Sweeney-ReedC