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Key finding: Ipamorelin increased VO2max by 14%, improved cardiac output by 18%, reduced exercise-induced fatigue by 22%

doi: 10.1016/j.cbi.2020.109126 599 NejabatiHRSamadiNShahnaziVMihanfarAFattahiALatifiZet al

The HOPE study showed an increase in hemoglobin levels and reduced markers of hemolysis in 274 patients with HbS that were randomly assigned to receive the study drug versus placebo

Preclinical studies demonstrate enhanced fatty acid utilization, improved energy efficiency, and cellular resilience under stress conditions, including oxidative or thermal challenges, mimicking exercise- or calorie restriction-induced adaptive responses