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The anti-inflammatory effects resulting from using resveratrol can be seen in the reduction of increased levels of interleukin and TNF in obese mice (153) and reduced OxS markers like glycated albumin levels in serum and 8-hydroxyguanosine in urine in stroke-prone spontaneously hypersensitive rats (154)

623 The side effects of NAD + boosting The aforementioned findings suggest that elevating NAD + levels by administration of NAD + precursors, including NMN, NR, NAM, and NA, is a rational therapeutic strategy to improve a healthy lifespan

To investigate the role of caspase-3 on NET formation, mouse neutrophils were pretreated with caspase-3 inhibitors, including Q-VD (10 M), Z-VAD (30 M), emricasan (10 M) or a DMSO vehicle control for 30 min, followed by PMA stimulation (100 nM) for 6 h at 37 C