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There, it interacts directly with enterocytes and the enteric nervous system, triggering the motility-suppressing effects described above

The effect of rooibos (Aspalathus linearis), Honeybush (Cyclopia intermedia) and Sutherlandia (Lessertia frutescens) on testicular insulin signalling in streptozotocin-induced diabetes in wistar rats

FK866-induced NAD + depletion skewed monocytes/macrophages away from a pro-inflammatory towards an anti-inflammatory phenotype, thereby effectively ameliorating experimental colitis in vivo and diminishing pro-inflammatory cytokine release from human inflammatory bowel disease (IBD)-derived lamina propria mononuclear cells comparably to dexamethasone or infliximab in vitro [90]

Microb Pathog 100:7074 Abram F, Su W-L, Wiedmann M, Boor K, Coote P, Botting C, Karatzas K, OByrne C (2008) Proteomic analyses of a Listeria monocytogenes mutant lacking B identify new components of the B regulon and highlight a role for B in the utilization of glycerol