glutathione peroxidase type 2 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis - Liu - 2021 - Clinical and Translational Medicine Characterization of a patient-derived variant

Chung, Massachusetts General Hospital and Harvard Medical School Background : Hepatic stellate cell (HSC) and Kupffer cell activation are accompanied by increased expression of chemokines and chemokine receptors, including CC-chemokine receptor 2 (CCR2)

Under normal conditions, ROS production and elimination are balanced and play a role in promoting immunity and regulating the cell cycle ( Redox homeostasis is determined by the balance between ROS generation and ROS quenching capacity

1878-A INDIVIDUALIZED HCV TREATMENT FOR PWIDS ON OPIOID AGONIST THERAPY LED TO EXCELLENT ADHERENCE THROUGHOUT THE COVID19 PANDEMIC Caroline Schwarz 1,2 , Angelika Schtz 3 , Raphael Schubert 3 , Michael Schwarz 2 , Anika Jenke 3 , David Josef Maria Bauer 1,2 , Lukas Burghart 1,2 , Benjamin Steinwender 3 , Enisa Gutic 1 , Thomas Reiberger 2,4 , Hans Haltmayer 3 and Michael Gschwantler 1,5 , (1)Klinik Ottakring, (2)Medical University of Vienna, (3)Suchthilfe Wien Ggmbh, (4)Cemm Research Center for Molecular Medicine of the Austrian Academy of Sciences, (5)Sigmund Freud University Background: Directly observed therapy (DOT) with DAAs (direct-acting antivirals) is successful in eliminating HCV in PWIDs (people who inject drugs) on opioid agonist therapy (OAT): DAAs are prescribed via a low-threshold facility (LTF), and supervised DAA administration alongside OAT is performed at a pharmacy or LTF

Results: A3907 showed positive effects on liver weight, fibrosis progression, lobular inflammation, and steatosis scores