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Further, an LPS administration model of systemic inflammation in sepsis in conjunction with convulsant PTZ treatment in mice increased seizure susceptibility, which was attenuated with NOX2 genetic ablation and inhibition ( Epileptic encephalopathies and genetic epilepsies such as West, Lennox-Gastaut, Dravet, Lafora, and Leigh syndromes have additionally shown evidence of gliosis and neuroinflammation in humans (You et al., 2009

In the study of SARD, ML has proven useful in developing prediction models for diagnosis and disease outcomes and in elucidating pathogenesis [reviewed in (185)]