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You may also benefit from a B12 supplement if you have an autoimmune disease that attacks the stomach lining or GI tract (like Crohns or celiac disease), have had weight-loss surgery, or are taking heartburn medications that suppress stomach acid, Graham says

Patients who are already managing the once-weekly injection cadence of Semaglutide or Tirzepatide and do not want to add daily injections are not good candidates for GHK-Cu, not because of any contraindication, but because they wont maintain the protocol consistently enough to see results