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Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade

Among them, SEPT9 encodes a GTP-binding protein, which plays a role in cytokinesis, intracellular material transport, cell cycle regulation, and apoptosis ( 4 -treated mouse liver, and SEPT9 protein expression is significantly reduced, leading to increased ECM accumulation and aggravated fibrosis compared with that in controls