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Description

BioXCell) and 0.5 mg/mouse of rat anti-mouse CD8a mAb (clone 2.43

# 6500, Cat

In contrast to BRAF V600E melanoma cell lines, CRC cell lines present higher activity of PI3K/AKT pathway and lower levels of phosphorylated MEK, ERK, RSK, cyclin-D1 and Myc ( V600E in melanoma, dabrafenib and vemurafenib were approved drugs for CRC treatment

Overall, ICARIA-MM enrolled a more refractory patient population compared with APOLLO: at baseline, patients in ICARIA-MM had received more prior therapy lines (median, 3 vs