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[12] The glutathione molecule binds in a cleft between N - and C -terminal domains - the catalytically important residues are proposed to reside in the N -terminal domain

The NF-B signaling pathway is involved in pro-inflammatory molecule regulation (TNF-, IL-1, IL-6), immune responses, cellular proliferation, and apoptosis in both physiological and pathological contexts

3.3 Alleviation of oxidative stress Oxidative stress and neuroinflammation constitute a vicious cycle that serves as a core mechanism driving BBB dysfunction

It can have both a negative effect, such as HFD inducing metabolic endotoxemia, or a positive effect, such as a diet rich in plant polyphenols or fermented dairy products, increasing the expression of TJ proteins and promoting the development of beneficial bacteria