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Taken together, these results suggest that ALA may play a key role in enhancing the antioxidant capacity of the cells and reducing their susceptibility to death by ferroptosis

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Hence, there is a need for fine-tuned engineering strategies that not only improve pharmacokinetic properties, but also enhance specific effector functions with a minimum of amino acid substitutions to reduce the risk of immunogenicity

At each time point (five minutes intervals), photoluminescence spectra was recorded using a FluoroMax 4 (Horiba, Jobin Yvon GmbH, Unterhaching, Germany) spectrophotometer working with a continuous 450 W xenon lamp at ex / em of: 365/605, 552/636 and 495/519 nm for PLGA encapsulating DDA-GSH-AuNCs, Nile red or fluorescein, respectively