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Certain infections can affect your sense of smell and cause a metallic taste in the mouth, including: Bacterial infections Fungal infections Hepatitis HIV Helicobacter pylori Lyme disease Hansens disease Syphilis Cytomegalovirus COVID-19 Sinus infections Medications /Supplements Many medications can cause a metallic taste as a side effect, such as Antibiotics Antidepressants Antihistamines Blood pressure medications Chemotherapy drugs Supplements comprising iron , zinc, calcium, or multivitamins can also temporarily alter taste