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The current standard-of-care GBM therapeutic protocol, regardless the status of the molecular indicators of disease severity, includes the maximal safe surgical resection while preserving neurological function, followed by radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide (TMZ) [2, 3]

For example, Zamil et al 4 found that at least three vitamin A supplements were teratogenic, and four contain doses that exceed the recommended daily level of intake