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J Nat Prod 67(2):129135 Fan T-P et al (2006) Angiogenesis: from plants to blood vessels

Key Safety Considerations Despite its biological activity, IGF-1 LR3 raises several concerns: Blood glucose disruption: hypoglycemia is a known risk Fluid retention and musculoskeletal discomfort: commonly reported Metabolic effects: potential insulin resistance with extended exposure Oncogenic signaling: persistently elevated IGF-1 levels have been linked to certain cancers Regulatory Reality Not FDA-approved for therapeutic or lifestyle use Banned in competitive sports by anti-doping agencies Limited clinical evidence: lacks robust, long-term human safety trials A Cautious Outlook While IGF-1 LR3 provides valuable insights into growth factor biology, its translation beyond controlled research environments remains unresolved

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As a result, the residual H 2 O 2 levels may not be sufficient to significantly modulate catalase expression, which could explain the unchanged catalase levels observed following ALA treatment