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This more aggressive approach, starting immediately with anti-TNF treatment, preferably in combination with an immunomodulator, might be needed in patients with acute severe UC

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Furthermore, these drugs do not cure nor reverse the disease, which leaves patients and their families feeling increasingly despondent (Wang and Reddy, 2017

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After 4 h of infection, the cells were washed thrice with 1X PBS to remove the extracellular bacteria and replenished with fresh media

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Robin Blythe, Duke-NUS Medical School, Singapore

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