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DCHD can effectively improve pancreatic fibrosis by inhibiting the infiltration of pancreatic macrophages and the secretion of inflammatory factors ( Sulindac is an aryl chain acid non-steroidal anti-inflammatory drug that is reversibly converted to sulindac sulfide, an anti-inflammatory active compound in the body that inhibits COX-1 and COX-2 activities, reduces prostaglandin(PG) synthesis, and exerts analgesic and anti-inflammatory effects (116)

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In brief, HUVECs were lysed in Co-IP buffer containing 20 mM Tris-HCl (pH 7.5), 100 mM NaCl, 0.5 mM EDTA, 0.5% NP-40, 0.5 mM PMSF, and 0.5% protease inhibitor cocktail on ice for 20 min

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