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En quienes tienen uremia puede generar debilidad muscular, y convulsiones en quienes padecen de trastornos convulsivos

Supplementation with GSH is generally ineffective at increasing cellular glutathione levels because most human cells cannot uptake extracellular GSH due to the lack of the membrane-bound ectoenzyme -glutamyltranspeptidase (-GT) or due to an unfavorable concentration gradient across the cell membrane 10,16