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Materials and Methods According to Par and Kitsiou [12] and the PRISMA-S checklist [13], we conducted a comprehensive literature review using PubMed, Web of Science, and Medline

Epitalon's chromatin remodeling effect demonstrated in Khavinson's 2003 work on heterochromatin activation in aged cells removes structural barriers to gene expression that would otherwise limit GHK-Cu's transcriptional effects.11 Epitalon opens the chromatin

Initial clinical trials only tested a gap of less than six months between doses, but unexpected popularity and resulting shortages caused further testing to validate wider spacing of the two doses

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