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doi: 10.1007/s11434-013-0058-8

These linkers do not release the drug until the ADC is internalized and the antibody component is degraded within the lysosome, ensuring that the cytotoxic agent is not unleashed at off-target sites

Finally, abundant competing cations such as high concentrations of Ca 2+ in calcareous soils, , H + , and Al 3+ in acidic soils, or Na + in saline soils, counteracted Mg 2+ to reduce its availability to crops (Mengel et al., 2001

Markers of oxidative damage have been observed in transgenic animal models of AD 48,49,50 , as well as the brains of individuals with mild cognitive impairment (MCI) 51,52 , Down Syndrome (DS) 53,54 , and AD 55,56,57