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Description

Occasionally used off-label for fibromyalgia, restless leg syndrome, anxiety Pharmacokinetics Absorption: Oral, dose-dependent bioavailability (decreases at higher doses) Distribution: Not highly protein-bound Metabolism: Minimal hepatic metabolism Excretion: Renal (adjust dose in renal impairment) Half-life: 57 hours Adverse Effects Common: dizziness, somnolence, ataxia, fatigue Less common: peripheral edema, tremor, blurred vision Rare: hypersensitivity reactions, mood changes Pregnancy / Lactation Pregnancy: Limited human data