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BBB dysfunction in these pathologies may result in compromised transport and permeability properties of the barrier as well as in alterations in cerebrovascular regulatory mechanisms of blood flow, with ensuing perturbed signalling between brain endothelium and associated cells, such as glia and neurons

Organ suspensions were subjected to serial 3-, 5- or 6-fold dilutions (depending on the state of disease progression) in modified Schneiders Drosophila medium (Leitherer et al, 2017), with 12 replicates per dilution step