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Description

TMAO reduces bile acid pools, inhibiting FXR activity, disrupting bile acid-FXR signaling, and upregulating pathways worsening hepatic steatosis, as confirmed in HFD-fed C57BL/6J mice and human samples (154)

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In animal and in vitro studies, IPA has been shown to exert cytostatic effects in cancer and to alleviate rheumatoid arthritis, steatohepatitis, and muscle protein breakdown in inflammatory states [135,226,261,262]

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