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Oceanic nickel depletion and a methanogen famine before the Great Oxidation Event

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Foundational studies have demonstrated that ATP-citrate lyase links mitochondrial-derived citrate metabolism to nuclear histone acetylation, establishing a direct connection between cellular metabolism and chromatin regulation (Wang et al., 2024)

doi: 10.1016/j.cell.2007.02.039

Analysis using the Broad Institutes Connectivity Map database identified GHK as one of the top two compounds (from 1,309 bioactive molecules screened) recommended for study in aggressive metastatic colon cancer models