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There was a counteraction of L-NAME worsening and upgrading of otherwise L-arginine-limited therapeutic effect [17]

Metformin can reduce the vacuolated PTECs, dilated tubules, collagen deposition, and mitochondrial morphological abnormalities to protect PTECs from the impact of FA/IRI by activating the AMPK pathway and promoting the SENP1-SIRT3 axis in FA/IRI-induced AKI mice model