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IL-1 and TNF- inhibit GABAergic neurons in the VLPO, reducing their inhibitory tone on wake-promoting regions such as the locus coeruleus and orexinergic hypothalamic neurons

The patient continues dosing without therapeutic effect

67 Proteaseanti-proteases imbalance during airway inflammation and airflow restriction may be an important factor affecting airway remodelling and airflow restriction

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Sitohy B., Chang S., Sciuto T.E., Masse E., Shen M., Kang P.M., Jaminet S.C., Benjamin L.E., Bhatt R.S., Dvorak A.M., et al