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Because it is a mitochondrial-derived peptide tied to energy biology, it has been folded into broader narratives about healthy aging, metabolic resilience, and "optimizing" mitochondrial function

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Due to the lack of GH and GHR on the regulation of mitophagy, we proposed that these discrepant results of GH and GHR on mitochondrial function may be explained by the coordinated regulation mechanism between mitochondrial biogenesis and mitophagy to meet different physiological conditions in vivo and in vitro

Calibration curves for HepG2 and HepG2 ATP7B-KO cells were generated according to manufacturers instructions by plating 40,000, 20,000, 10,000, 5,000, 2,500, 1,250, 652, 312, 156 and 0 cells in 100 l Medium without CuCl 2 and CuSO 4 in a 96-well-plate