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doi: 10.3389/fimmu.2026.1769281 Received 16 December 2025 Revised 08 April 2026 Accepted 13 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Douglas Sborov, The University of Utah, United States Reviewed by Nomie Leblay, University of Calgary, Canada Xuan Jiang, Shanghai Jiao Tong University, China Updates Copyright 2026 Horenstein, Frerichs, Faini, van de Donk and Malavasi

In addition, most B12 supplements come in the form of pills, and most people do not receive the full benefit from digesting a pill while some cannot absorb the nutrients at all

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For people with an MTHFR mutation, methylcobalamin (as opposed to other forms of B12) is therapeutic