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A.OBrienJ.BlackS.ChenC.DeCarliC.ErkinjunttiT.et al (2017)

Intertumoral Heterogeneity One of the biggest challenges in treating GBM is intertumoral heterogeneity, which refers to the fact that different regions within a single GBM tumor can have different molecular and genetic profiles

Lipid nanocapsules (LNCs), solid lipid nanoparticles (SLNs), and suspensions were also investigated for hispolon loading

The results are consistently positive and the mechanistic data is compelling, but as of 2026 there are no completed Phase 3 human randomized controlled trials