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Besides that, A-T is a rare disease (OMIM 208,900) in which incidence ranges from 1: 40,000 to 1: 100,000, and it is caused by a mutation in the ATM gene (ataxia-telangiectasia mutated)

Notably, recent in vitro and in vivo studies have revealed that REV-ERB agonists (SR9009 and SR9011) exhibit selective anticancer properties in brain, leukemia, breast, colon, and melanoma cancer cell lines by inhibiting autophagy and de novo lipogenesis important for cancer cell survival 45,84,85

While it can occur in young people, the chance of getting osteoarthritis rises after age 45

As their primary gene products, the fibers elaborate the predominant proteins of the lens, called crystallins