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The hydrophilic nature and large molecular weight of these molecules prevent passive diffusion across enterocytes, and paracellular transport is restricted by TJ complexes, which typically exclude molecules larger than 1 nm or 600 Da (Shen et al., 2011

Peptide Vials (AOD-9604, 2 mg each): 8 weeks 12 vials 12 weeks 19 vials 16 weeks 26 vials Insulin Syringes (U100): Per week: 7 syringes (1/day) 8 weeks: 56 syringes 12 weeks: 84 syringes 16 weeks: 112 syringes Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial for reconstitution

When the lining of the intestines becomes permeable, this facilitates the free passage of toxins, bacteria, and undigested food particles into the bloodstream

They were removed because the original nominators withdrew their nominations, which allowed the FDA to refer them to the Pharmacy Compounding Advisory Committee (PCAC) for formal review