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BrM secretes signals that redirect monocyte-derived macrophages and microglia toward immunosuppressive phenotypes, which show patterns of gene expression dominated by type 1 interferon (IFN) activity and checkpoint signaling ( + T cells, with context-dependent mechanistic contributions from B cells, plasma cells, and Tregs, which all help the tumor evade immune attack ( Collectively, the immune escape mechanisms including checkpoint upregulation, cytokine cross-talk, and myeloid remodeling produce an immune-excluded tumor milieu

In fact, KGFs have been shown to promote the healing of gut epithelium in individuals with IBD and improve gut barrier function [133]

Anthoney DA, McIlwrath AJ, Gallagher WM, Edlin AR and Brown R

Ruenraroengsak P, Novak P, Berhanu D, Thorley AJ, Valsami-Jones E, Gorelik J, et al