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Patients suffering from neurological disorders such as PD have been reported to have decreased plasma levels of vitamin C

Significance was calculated by using the tests indicated in figure legends including PERMANOVA, Friedman test followed by Dunns multiple comparison test and RM-One-Way ANOVA with Geisser-Greenhouse correction followed by Dunnetts multiple comparison test

These include beta-blockers, ACE inhibitors, nonsteroidal anti-inflammatory drugs, thiazide diuretics, antimalarials, and specific types of antibiotics ( 2.2 Pathogenesis of oral lichen planus The initiation of OLP is driven by the interplay between various immune cells, the cytokines and chemokines they release, and extracellular matrix proteins, collectively activating multiple pathogenic pathways ( In physiological status, keratinocytes discharge type IV collagen and laminin, emitting signals that inhibit apoptosis within the epithelial cells, which is essential for upholding the integrity of the basement membrane ( On the other hand, activated lymphocytes and keratinocytes can release a proinflammatory cytokine RANTES, leading to the degranulation of mast cells, which then prompts the release of TNF- and chymase