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Together, our data indicate that not only the mutant or WT status of Rb but also the expression levels of FZR1 and functional activity of the APC/C FZR1 E3 ligase will determine how cancer cells respond to CDK4/6 inhibitor treatment

Injection Site Reactions : Bruising can be normal after injections, but persistent redness or swelling may be a sign or either a reaction or infection in that area