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3 The BR in Parkinsons disease (PD) Bilirubin may be involved in the pathogenesis of PD through oxidative stress, inflammation, mitochondrial dysfunction, glutamate toxicity, and autophagy

The author reported augmented deposition of collagen, oxidative stress, and phosphorylated p38 protein in DNP rats, which were reversed by melatonin ( Melatonin alone or in combination with drugs such as gabapentin enhanced the hepatic gene expression of peroxisome proliferatoractivated receptor and mitochondrial transcription factor-A