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There could be a threshold of mitochondrial stress at which mitophagy is engaged, but at levels that can manage a wide range of elevated IOP and attendant hypoxia

Comprehensive understanding of the pathophysiology is key for better diagnostics and therapy targets

Manoli I, Sysol JR, Li L, Houillier P, Garone C, Wang C, Zerfas PM, Cusmano-Ozog K, Young S, Trivedi NS, Cheng J, Sloan JL, Chandler RJ, Abu-Asab M, Tsokos M, Elkahloun AG, Rosen S, Enns GM, Berry GT, Hoffmann V, DiMauro S, Schnermann J, Venditti CP

Kumaran S, Panneerselvam KS, Shila S, Sivarajan K, Panneerselvam C: Age-associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: role of carnitine and lipoic acid