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Results RGMa expression is upregulated in the granular cell layer of the dentate gyrus in db/db mice The db/db mouse, homozygous for spontaneous leptin receptor mutations, has been used as a model of type 2 diabetes mellitus

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Proc Natl Acad Sci USA 1992;89:51715175

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Direct action on the hypothalamic-pituitary-gonadal axisand thus on testosterone productionremains speculative

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