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Massive mobilization of AML, cells into circulation by disruption of leukemia/stroma cell interactions using CXCR4 antagonist AMD3100: First evidence in patients and potential for abolishing bone marrow microenvironment-mediated resistance

Prior studies in rats demonstrated that Polysaccharide Iron Complex (PIC), administered as a single oral dose to Sprague Dawley rats did not produce evidence of toxicity at a dosage level of 5000 mg Iron/kg: (An Acute Oral Toxicity Study in Rats with Polysaccharide-Iron Complex

however two days following treatment with diphtheria toxin, the macrophage pool is replenished by circulating macrophages, which in turn, have been replenished by bone marrow-derived monocytes

Middle-sized peptides between small molecules and antibodies can be used for targeting undruggable intracellular proteinprotein interactions [146, 147]