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Hemizygous FcRn transgenic mice (B6.Cg-Fcgrt tm1Dcr Tg(FCGRT)32Dcr/DcrJ) (Tg32) that are knockout for the mouse FcRn heavy chain (Fccgrt tm1Drc ) and express the genomic transgene of the human FcRn heavy chain (FCGRT) under the control of the human FcRn promotor (Tg32) (The Jackson Laboratory) were used to measure the plasma half-life of IgG variants and etanercept