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Indeed, through electrostatic interactions, cationic NEs can penetrate and remain on the anionic ocular surface for a long period, thus providing a suitable choice for non-invasive drug delivery into the posterior ocular segment and increasing drug bioavailability

Soluble proteins classically contain N-terminal signal peptides that direct them to the translocation apparatus of the Endoplasmic Reticulum (ER) (Walter et al., 3 ), impairs SOD1 export (Mondola et al., A4V , another mutant form of SOD1, were not detected in the ER in NSC-34 cells

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