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Sci Rep 16 , 12711 (2026)

Mechanistic and Translational Studies Preclinical research in rodent models has characterized the additive effects of amylin and GLP-1 receptor activation on hypothalamic appetite circuits, energy expenditure, and gastric emptying

Therefore, analog synthesis focuses on modification of these positions with the goal of improving microsomal and plasma stability in vitro and with the ultimate goal of producing analogs with improved in vivo properties for use in animal models of disease