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Additionally, SLC7A11 influences the immune response to therapy by regulating the redox balance and immune cell infiltration (such as inhibiting CD8 + T cell activity) in the tumor microenvironment, and its expression is subject to multi-level regulation by epigenetic modifications (such as m6A, ubiquitination) and transcription factors (NRF2, ATF4), offering diverse targets for the development of small molecule inhibitors, metabolic interventions (glucose deprivation), or combination therapies (such as with immune checkpoint inhibitors)

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This pathway-level enrichment is directly corroborated by our functional co-expression network, which highlights the up-regulation of key metabolic nodes such as AmPCT2 (phenylalanine biosynthesis) and AmAGBE3 (starch and sucrose metabolism)

Thiamine supplementation has been shown to improve left ventricular ejection fraction after several weeks of treatment (94)