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The concept of trained immunity poses that long-term functional changes in innate immune cells can be induced by certain challenges, which are mediated by epigenetic reprogramming of innate immune cells and their stem/progenitor cells

However, part of this evidence derives from populations with other psychiatric disorders ( Post-transcriptional regulation mediated by microRNAs (miRNAs) has also emerged as a component in the epigenetic interface between inflammation, HPA axis functioning, and depression

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S.Board of Directors of the American Headache Society (2021)