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AMPK is a dominant negative regulator of mTORC1

Given the predicted reductase activity of Rha1 and Rha2 and their structural similarity to proteins that metabolize enone-containing compounds, we further investigated their role in 4-HNE resistance

10.1016/j.plaphy.2013.10.012 53 SchippersJ

One such example is glucagon-like peptide 1 (GLP-1) (3.3 kDa), a small peptide hormone with a plasma half-life of only two minutes due to enzymatic degradation by dipeptidyl peptidase-4 (DDP-4) in the blood and rapid excretion through the kidneys 16,17,18,19