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Sequential versus simultaneous initiation : Many clinicians prefer establishing tirzepatide tolerance and efficacy before adding other therapies, allowing clearer attribution of benefits and adverse effects

Results Children with concomitant IR showed exacerbated metabolic disturbances in the crosstalk between endogenous, microbial, and environmental determinants, including failures in energy homeostasis, amino acid metabolism, oxidative stress, synthesis of steroid hormones and bile acids, membrane lipid composition, as well as differences in exposome-related metabolites associated with diet, exposure to endocrine disruptors, and gut microbiota

P., Peters, W

In the study, researchers evaluated also the efficacy of other repurposed drugshydroxychloroquine, lopinavir, and interferon beta-1a