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It is indicated for patients with locally advanced or metastatic non-squamous NSCLC with high c-MET overexpression (50% of tumor cells showing 3+ strong staining by IHC)

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Confocal microscopy with tetramethylrhodamine methylester, calcein, propidium iodide, and dichlorodihydrofluorescein revealed a rapid burst of reactive oxygen species and onset of MPT in reperfused HFD hepatocytes, which was, however, blocked by mNT deletion

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