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Indeed this finding is similar to studies of ischaemic damage in the brain which show MG-mediated protection occurs in the presence of similar cytokines that we show are elevated here in the ischaemic retina, including sICAM, INF, IL-1, KC(CXCL1), MCP-5 (CCL12), MIP2(CXCL2) and TNF 57

Neuron 2:15471558 Murphy TH, Schnaar RL, Coyle JT (1990) Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake

Avoid sensitive areas: Be cautious when applying near sensitive areas such as the eyes, nostrils, mouth, or open wounds as Tretinoin may cause irritation

Cholestasis: This is defined as decreased or ceased bile flow and can be due to physical obstruction of bile flow or functional or inherited defects in the transporters that deliver bile salts (the bile salt export pump, BSEP) or bilirubin (MRP2) into the biliary system