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This narrows arteries, raises blood pressure, and causes damage to organs like the liver, heart, and pancreas

Due to these mechanical circumstances, the cartilage in these knees is subject to complex stresses that are significantly greater in magnitude than those the healthy green knee would experience

The central role of mitochondrial dysfunction in PD As the energy and metabolic hub of cells, mitochondrial dysfunction is a core feature of the pathophysiology of PD [17]