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However, environmental interactions are known to modulate the protective effects of this allele, and this was demonstrated by a study where the investigators found an increase of this allele (2.5% to 13% between 1979 and 1992) in Japanese individuals who consumed alcohol ( A meta-analysis of 50 association studies of variants reported in genes namely ADH2, ADH3, CYP2E1 , and ADLH2 reported significant associations of ADH2*1, ADH3*2, and ALDH2*1 alleles with the risk of alcoholism ( A study that genotyped for variants in ADH2, ADH3, CYP4502E1 (Pst-I and Dra-I), and ALDH2 in Spaniard alcoholic subjects (without liver disease, with non-cirrhotic liver disease, and with cirrhosis) and compared with non-alcoholic subjects (healthy controls with non-cirrhotic non-alcoholic liver disease and with cirrhosis unrelated to alcohol) reported that variants in the studied genes were not related to alcoholism or susceptibility to alcoholic liver disease in addition to ALDH2 locus being monomorphic ( Variants known to predict alcohol sensitivity are currently being investigated by firms that offer variant-based testing directly to consumers under nutrigenetics testing

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doi: 10.1007/s13311-021-01111-9 121 ZhangHWangYWangSXueXHuangKXuDet al